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Carole Vogler Selected Research

Lysosomal Storage Diseases (Lysosomal Storage Disease)

10/2012Biochemical evidence for superior correction of neuronal storage by chemically modified enzyme in murine mucopolysaccharidosis VII.
5/2010Therapeutic efficacy of bone marrow transplant, intracranial AAV-mediated gene therapy, or both in the mouse model of MPS IIIB.
4/2010New strategies for enzyme replacement therapy for lysosomal storage diseases.
6/2008Infused Fc-tagged beta-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice.
5/2008A murine model of infantile neuronal ceroid lipofuscinosis-ultrastructural evaluation of storage in the central nervous system and viscera.
2/2008Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.
10/2006Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors.
10/2005Overcoming the blood-brain barrier with high-dose enzyme replacement therapy in murine mucopolysaccharidosis VII.
7/2005Early onset of lysosomal storage disease in a murine model of mucopolysaccharidosis type VII: undegraded substrate accumulates in many tissues in the fetus and very young MPS VII mouse.
6/2004Human CD34+ hematopoietic progenitor cell-directed lentiviral-mediated gene therapy in a xenotransplantation model of lysosomal storage disease.
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Carole Vogler Research Topics

Disease

17Lysosomal Storage Diseases (Lysosomal Storage Disease)
10/2012 - 01/2003
15Mucopolysaccharidosis VII (Sly Syndrome)
10/2012 - 11/2002
6Mucopolysaccharidoses
10/2012 - 12/2003
3Globoid Cell Leukodystrophy (Krabbe Disease)
01/2014 - 09/2005
3Mucopolysaccharidosis III (Sanfilippo Syndrome)
10/2012 - 08/2007
2Demyelinating Diseases (Demyelinating Disease)
01/2014 - 01/2007
2Mucopolysaccharidosis I (Hurler Syndrome)
08/2011 - 05/2007
2Neurodegenerative Diseases (Neurodegenerative Disease)
05/2008 - 01/2007
2Neoplasms (Cancer)
07/2007 - 03/2003
2Mucopolysaccharidosis IV (Morquio Syndrome)
07/2007 - 12/2003
1Infarction (Infarctions)
06/2019
1Edema (Dropsy)
06/2008
1Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome)
05/2008
1Seizures (Absence Seizure)
05/2008
1Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis)
05/2008
1Blindness (Hysterical Blindness)
05/2008
1Hepatocellular Carcinoma (Hepatoma)
07/2007
1Brain Diseases (Brain Disorder)
05/2007
1Chronic Renal Insufficiency
05/2007
1Drug-Related Side Effects and Adverse Reactions
05/2007
1Gliosis
01/2007
1Gaucher Disease (Gaucher's Disease)
10/2006
1Central Nervous System Diseases (CNS Diseases)
09/2005
1Joint Diseases (Joint Disease)
05/2004
1Disease Progression
04/2004
1Inborn Genetic Diseases (Disease, Hereditary)
01/2003

Drug/Important Bio-Agent (IBA)

15EnzymesIBA
01/2014 - 03/2003
13GlucuronidaseIBA
10/2012 - 11/2002
4GlycosaminoglycansIBA
08/2011 - 04/2004
3GalactosylceramidaseIBA
01/2014 - 09/2005
2Iduronidase (alpha-L-Iduronidase)IBA
08/2011 - 05/2007
2alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)IBA
05/2010 - 08/2007
2Hexosaminidases (Hexosaminidase)IBA
05/2010 - 08/2007
2Proteins (Proteins, Gene)FDA Link
05/2008 - 07/2007
2SulfatasesIBA
07/2007 - 12/2003
2Keratan SulfateIBA
07/2007 - 12/2003
1Lipase (Acid Lipase)FDA Link
06/2019
1PerT-GUSIBA
10/2012
1CarbohydratesIBA
10/2012
1N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA
10/2012
1OligopeptidesIBA
06/2008
1Acidic Amino AcidsIBA
06/2008
1Fatty Acids (Saturated Fatty Acids)IBA
05/2008
1PerforinIBA
05/2008
1MicroRNAs (MicroRNA)IBA
07/2007
1Cysteine (L-Cysteine)FDA Link
07/2007
1Sulfates (Sulfates, Inorganic)IBA
07/2007
1Immunosuppressive Agents (Immunosuppressants)IBA
05/2007
1Recombinant ProteinsIBA
05/2007
1Mannose (D-Mannose)IBA
10/2006
1Mannose ReceptorIBA
10/2006
1Lysergic Acid Diethylamide (LSD)IBA
06/2004
1Peptides (Polypeptides)IBA
03/2004

Therapy/Procedure

8Enzyme Replacement Therapy
10/2012 - 03/2004
4Therapeutics
05/2008 - 01/2003
2Heterologous Transplantation (Xenotransplantation)
06/2004 - 03/2003
1Transplantation
01/2014
1Injections
05/2007
1Kidney Transplantation
05/2007
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2007
1Enzyme Therapy
10/2006